One one hand, the Fallout games up to know have always made certain events and decisions that can happen based on a player's decision canon in the sequels.
And personally, I'm kinda torn on the issue. I remember reading some threads on other websites debating on which one would be considered canon. Each end up deciding the fate of New Vegas and the Mojave Wasteland forever. For those who don't know, Fallout New Vegas has several different kinds of endings. I've been playing some Fallout recently, and this has been on my mind for a while.
